Delivering Antibodies via mRNA Could Prevent RSV Infection

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3D super-resolution microscopy cross-sectional image showing how the engineered antibody aPali works: aPali (green) is expressed on the cell surface and stops RSV particles (pink) from entering the cell.

Stitched confocal microscopy image of RSV-infected mouse lung. RSV nucleoprotein and fusion proteins appear red and green, respectively. Cell nuclei appear blue.

Graduate student Daryll Vanover, professor Philip Santangelo and post-doctoral fellow Pooja Tiwari were co-authors on a study that used mRNA-expressed antibodies to prevent RSV infection in mice.